For some years now, my mailbox is flooded by CFPs for your many conferences such as WMSCI 2011 (for which you are General Chair etc.). My email address is firstname.lastname@example.org. Please remove me from your bulk mailing system. (I have tried your instructions for unsubscribing in the past, obviously, w/o success.)
Keep up the good work.
PS: It is not easy to set up a mail filter that addresses this problem reliably over the years. Or does anyone have an idea as to how to stretch gmail's filter mechanism? I can think of a rule that checks whether a) we face a CFP or some other form of conference ad, and b) certain keywords (names) occur on the website of the conference. Now, gmail, please provide us with that expressiveness :-)